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:: Volume 13, Issue 4 (Winter 2013) ::
J Ardabil Univ Med Sci 2013, 13(4): 406-412 Back to browse issues page
Assessment of Adding Fenofibrate to Simvastatin on Exercise Test Findings in Patients with Dyslipidemia and Coronary Artery Disease
Reza Karbasi Afshar, Ayat Shahmari, Eiman Lotfian, Amin Saburi
Abstract:   (5268 Views)

  Introduction : Cardiac events due to coronary artery disease (CAD) are the most common cause of death in all over the world. Myocardial ischemia and its consequent heart failure are considered as common problems and complications of CAD. The purpose of this study was to assess the anti-ischemic effects of fibrates in patients with CAD.

  Methods : This clinical-trial study was conducted on patients with dyslipidemia and CAD referred to the Baqiyatallah university hospital, Tehran, during 2008-2010. A total of 124 patients randomly divided into two groups: the first group (64 patients) received simvastatin (20-60 mg/day)+fenofibrate (200 mg/day) with lipid-limited diet and exercise and the second group (60 patients) received simvastatin (20-60 mg/day) with diet and exercise for one year and the patients were evaluated at the end of this period.

  Results : The mean age was 54.3±6.5 years and 53.2% of patients were male. Metabolic equation index was changed from 4.32±0.5 to 5.68±0.5 at the first group (P<0.001) and 4.43±0.9 to 4.41±1.1 at the other one (P=0.121) and also time of exercise was changed from 5.21±1.81 to 6.01±1.8 (P<0.001) and 5.43±1.26±5.23±1.2 (P=0.089) respectively. No serious adverse effects were seen.

  Conclusion : Lipid-lowering therapy with simvastatin and fenofibrate reduces myocardial ischemia. Therefore it’s recommended to add fenofibrate to statinsin the treatment of dyslipidemia in patients with high risk of cardiovascular accidents as complementary treatment.

Keywords: CAD; Dyslipidemia; Exercise Test; Simvastatin; Fenofibrate
Full-Text [PDF 305 kb]   (1685 Downloads)    
Type of Study: article | Subject: Special
Received: 2012/07/11 | Accepted: 2013/05/31 | Published: 2013/12/22
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Karbasi Afshar R, Shahmari A, Lotfian E, Saburi A. Assessment of Adding Fenofibrate to Simvastatin on Exercise Test Findings in Patients with Dyslipidemia and Coronary Artery Disease. J Ardabil Univ Med Sci. 2013; 13 (4) :406-412
URL: http://jarums.arums.ac.ir/article-1-31-en.html


Volume 13, Issue 4 (Winter 2013) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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