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:: Volume 12, Issue 2 (summer 2012) ::
J Ardabil Univ Med Sci 2012, 12(2): 149-156 Back to browse issues page
Relation of Vitamin D3 Level with metabolic Syndrome Indices among Patients with Diabetes and Non-Diabetic Individuals
Amir Ziaee , Sima Hashemipoor, Taktom Karimzadeh, Azadeh Jalalpoor, Amir Javadi
Abstract:   (7530 Views)

  Background & objectives: There are growing evidences about relationship between vitamin D metabolism and occurrence of diabetes mellitus. Vitamin D has a role in secretion and possibly the action of insulin and modulates lipolysis and might therefore contribute to the development of cardiovascular diseases. This study was aimed to evaluate whether serum vitamin D3 level in patients with diabetes is lower than that in non-diabetics and if its level has any relation to indices of metabolic syndrome.

 Methods: Sixty nine subjects were enrolled in this case-control study (23 diabetic patients with good control of blood sugar, 23 poor control diabetic patients and 23 healthy subjects as control group). Serum 25(OH) D3, Fasting Blood Sugar (FBS), (2 hour postprandial blood sugar) BS 2hpp, triglyceride (TG), total cholesterol, HDL and HbA1C were measured. We also measured blood pressure, body weight, height and abdomen circumference for individuals. The data were analyzed by Anova, Chi-square and Pearson correlation.

 Results: Serum levels of Vitamin D3 were significantly lower in diabetics compared to non diabetics. (36/5±16/6 v.s. 56/6±19/1 nmol/lit, p<0/001). There was no statistical difference between the group with good control diabetes and poor control diabetes. There was no significant correlation between low serum vitamin D and metabolic syndrome parameters. These findings suggest the need for ongoing evaluation of possible protective role of vitamin D3 supplement in the development of diabetes.

 Conclusions: Based on our results vitamin D deficiency is prominent in patients with diabetes. It appears the vitamin D level should be monitored in diabetic patients.

Keywords: Diabetes; 25(OH) D3; Metabolic Syndrome
Full-Text [PDF 194 kb]   (2060 Downloads)    
Type of Study: article | Subject: Special
Received: 2011/08/16 | Accepted: 2012/01/30 | Published: 2012/06/21
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Ziaee A, Hashemipoor S, Karimzadeh T, Jalalpoor A, Javadi A. Relation of Vitamin D3 Level with metabolic Syndrome Indices among Patients with Diabetes and Non-Diabetic Individuals . J Ardabil Univ Med Sci. 2012; 12 (2) :149-156
URL: http://jarums.arums.ac.ir/article-1-137-en.html


Volume 12, Issue 2 (summer 2012) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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