[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 16, Issue 3 (autumn 2016) ::
J Ardabil Univ Med Sci 2016, 16(3): 232-240 Back to browse issues page
Effect of Simultaneous Use of Ritalin with Grape Seed Extract on Passive Avoidance Learning in Adult Male Rats
Tooba Karimizadeh Moneh, Ebrahim Hosseini
Department of Biology, Faculty of Basic Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Abstract:   (6892 Views)

Background & objectives: Ritalin is one of the drugs used in the treatment of attention-deficit/hyperactivity disorder (ADHD). This study aimed to investigate the comparative effect of Ritalin with grape seed extract on passive avoidance learning in adult male rats.

Methods: In this experimental study, 40 adult male Wistar rats divided randomly into 5 groups of 8 rats including control, sham and three experimental groups. The control group received no treatment. The sham group received 1 ml of distilled water per day. At the same time the experimental groups received 100 mg/kg grape seed extract, 1 mg/kg Ritalin or 100 mg/kg grape seed extract together with 1 mg/kg of Ritalin by gavage for 28 days. For measuring the amount of avoidance learning, Shuttle box was used. Data analyzed by ANOVA and consistent Tukey's tests using SPSS-18 software and p>0.05 considered as significant.

Results: The results showed that Ritalin decreases the passive avoidance learning, while the grape seed extract alone or together with Ritalin increases passive avoidance learning.

Conclusion:  The outcome of this research shows that taking Ritalin leads to decreasing passive avoidance learning. However, the simultaneous taking Ritalin with grape seed extract inhibits the Ritalin effect and increasing the learning.

Keywords: Ritalin, Grape Seed, Passive Avoidance Learning, Rat
Full-Text [PDF 129 kb]   (4112 Downloads)    
Type of Study: article | Subject: General
Received: 2016/03/10 | Accepted: 2016/08/31 | Published: 2016/10/1
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Karimizadeh Moneh T, Hosseini E. Effect of Simultaneous Use of Ritalin with Grape Seed Extract on Passive Avoidance Learning in Adult Male Rats. J Ardabil Univ Med Sci. 2016; 16 (3) :232-240
URL: http://jarums.arums.ac.ir/article-1-1165-en.html

Volume 16, Issue 3 (autumn 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.1 seconds with 32 queries by YEKTAWEB 4157