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:: Volume 16, Issue 2 (summer 2016) ::
J Ardabil Univ Med Sci 2016, 16(2): 178-188 Back to browse issues page
Effects of the Combination Therapy with ‍Candesartan and Alpha Tocopherol on Brain injury and Edema Following Brain Ischemia in Experimental Model of Transient Focal Cerebral Ischemia in Rats
Hamdollah Panahpour , Mohammad Nouri, Mohammadghasem Golmohammadi, Nooshin Sadeghian
Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract:   (4913 Views)

Background & objectives: Stroke is third leading cause of death and disability in the most of human communities. Several experimental studies have shown that combination therapy with drugs that act via different mechanisms can produce amplified protective effects. We examined the effects of combination therapy with candesartan and alpha tocopherol against cerebral ischemia.

Methods: Male Sprague-Dawley rats were divided into five groups (n=24): sham, control ischemic, candesartan treated (0.3 mg/kg), alpha tocopherol treated (30 mg/kg) and combined treated ischemic groups. Transient focal cerebral ischemia was induced by 90-min-long occlusion of the left middle cerebral artery followed by 24-h-long reperfusion. Neurological deficit score was evaluated at the end of the reperfusion period. Thereafter, the animals were randomly used for measurement of the infarct volumes and investigation of ischemic brain edema formation using a wet/dry method.

Results: Induction of cerebral ischemia produced considerable brain infarction in conjunction with severely impaired motor functions and edema formation. Combined treatment with candesartan and alpha tocopherol significantly reduced the infarct volume and lowered the water content in the ischemic lesioned hemisphere. These effects on brain edema and oxidative stress biomarkers were significantly more than the monotherapy with candesartan.

Conclusion: The combination therapy with candesartan and alpha tocopherol can noticeably decrease ischemic brain injury and attenuate edema formation likely via increasing the antioxidant activity.

Keywords: Stroke, Brain Edema, Candesartan, Alpha Tocopherol
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Type of Study: article | Subject: General
Received: 2016/04/28 | Accepted: 2016/06/9 | Published: 2016/06/29
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Panahpour H, Nouri M, Golmohammadi M, Sadeghian N. Effects of the Combination Therapy with ‍Candesartan and Alpha Tocopherol on Brain injury and Edema Following Brain Ischemia in Experimental Model of Transient Focal Cerebral Ischemia in Rats. J Ardabil Univ Med Sci. 2016; 16 (2) :178-188
URL: http://jarums.arums.ac.ir/article-1-1100-en.html


Volume 16, Issue 2 (summer 2016) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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